MTHFR, Methylation, and Its Impact on Health
“Genetics load the gun. Environment pulls the trigger.”
Methylation is a critical biochemical process that plays a key role in detoxification, neurotransmitter production, hormone metabolism, cardiovascular health, and DNA repair. When methylation is impaired due to variations in the MTHFR gene, it can contribute to a wide range of health issues, including:
- Depression and Anxiety
- Chronic Fatigue and Fibromyalgia
- Obesity
- Estrogen dominance (fibroids, endometriosis, irregular cycles)
- Elevated risk of cardiovascular disease (heart attack and stroke) and dementia
- Migraine headaches
- Autoimmune Disease
- Chemical Sensitivity
- Cancers
Homocysteine: A Key Marker of Methylation
Homocysteine is an important blood marker that reflects methylation efficiency. When methylation is impaired due to MTHFR variations, homocysteine levels can rise, increasing the risk of:
- Heart disease and stroke
- Chronic inflammation
- Cognitive decline
- Poor detoxification and hormonal imbalances
By evaluating homocysteine levels, Dr. Rajsree Nambudripad, MD, can assess methylation function and provide targeted nutritional support to optimize this essential pathway.
Supporting Methylation with Nutrition
Methylation efficiency can often be optimized through diet and targeted supplementation. Depending on your homocysteine level, Dr. Rajsree may recommend:
- Methyl B Complex – Provides essential B vitamins in their active forms to support methylation pathways
- Methyl B12 Tablet – Supports energy production, brain function, and detoxification
- Methylation Support – A combination of Methylfolate, Methyl B12, and Trimethylglycine to enhance methylation and reduce homocysteine levels
- Glutathione – The “master antioxidant” which also promotes detox pathways in our cells
A nutrient-rich diet is also key to supporting methylation. Dr. Rajsree encourages:
- Leafy green vegetables (rich in natural folate)
- High-quality protein sources (supporting amino acid metabolism)
- Cruciferous vegetables (which aid detoxification and hormone balance)
For a deeper understanding of MTHFR, methylation, and how to optimize your health, watch Dr. Rajsree Nambudripad’s video on MTHFR and Methylation:
Schedule a Consultation
If you suspect methylation issues may be affecting your health, Dr. Nambudripad can provide personalized guidance on homocysteine testing, methylation support, and targeted nutrition strategies.
Submit and application today to optimize your methylation pathways and support long-term wellness.
Dr. Rajsree is a caring and compassionate physician, who is board-certified in both Internal Medicine and Integrative/Holistic medicine. She is passionate about helping patients optimize their health through a preventative approach involving healthy lifestyle, dietary changes, targeted nutritional supplementation, and optimizing hormones. Her practice is unique in the personalized attention she devotes to each and every patient.