When your body starts reacting to everything, it’s time to look deeper.
Do you experience nasal congestion, acid reflux, anxiety, insomnia, skin rashes, or flushing after eating certain foods—even seemingly healthy ones?
Has your body become more reactive to temperature changes, emotional stress, or physical pressure?
These symptoms may not be due to a true allergy, but rather Histamine Intolerance or Mast Cell Activation Syndrome (MCAS)—two often-overlooked conditions rooted in immune dysregulation and gut microbiome imbalances.
What is Histamine Intolerance?
Histamine is a natural chemical involved in immune responses, digestion, and brain function. But when histamine builds up faster than your body can break it down, symptoms can occur—often mimicking allergies.
The key enzyme responsible for breaking down histamine is DAO (Diamine Oxidase), which is produced in the gut lining. In the setting of SIBO, Leaky Gut, or Dysbiosis, harmful bacteria can:
Degrade the DAO enzyme
Produce excess histamine
Weaken gut barrier function
This leads to histamine overload and systemic symptoms.
Dr. Rajsree’s Approach to Histamine Intolerance
Dr. Rajsree Nambudripad, MD has helped many patients overcome Histamine Intolerance by targeting the root cause—gut dysbiosis. Her video on Histamine Intolerance is one of the most widely viewed and informative resources on the topic, breaking it down with clear diagrams and real-world strategies.
Her treatment approach includes:
A short-term low histamine diet
Targeted gut-healing protocols
Key supplements that support histamine breakdown and immune balance, including:
What is Mast Cell Activation Syndrome (MCAS)?
MCAS is a complex condition in which mast cells, a key component of the immune system, become hyperactive and release chemical mediators like histamine inappropriately. Triggers can include:
Certain foods
Environmental changes
Physical pressure or vibration
Emotional stress
MCAS can make it feel like your body is reacting to everything—but many conventional doctors are unfamiliar with this diagnosis.
Dr. Rajsree has created one of the most informative videos on MCAS, providing clarity on symptoms, root causes, and a step-by-step approach to calming the immune system.
Healing Starts in the Gut
Because over 70% of the immune system is housed in the gut, healing the gut microbiome is central to calming histamine overload and mast cell reactivity. Dr. Rajsree combines her expertise in integrative medicine with advanced functional testing to uncover and address the root causes of immune dysregulation.
Ready to Begin Your Healing Journey?
If your body feels increasingly reactive and you’re struggling to find answers, Dr. Rajsree can help. Submit a new patient application today to begin your personalized path to healing.
Dr. Rajsree is a caring and compassionate physician, who is board-certified in both Internal Medicine and Integrative/Holistic medicine. She is passionate about helping patients optimize their health through a preventative approach involving healthy lifestyle, dietary changes, targeted nutritional supplementation, and optimizing hormones. Her practice is unique in the personalized attention she devotes to each and every patient.
